Description

Exendin-4 (Exenatide), originally isolated from Heloderma suspectum venom, stimulates acinar cAMP without causing amylase release, binds with similar affinity to the glucagon-like peptide 1 receptor, and is used in the treatment of type 2 diabetes.

SEQUENCE: H-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2

ONE-LETTER SEQUENCE: HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2

MOLECULAR FORMULA: C₁₈₄H₂₈₂N₅₀O₆₀S₁

MOLECULAR WEIGHT: 4186.7

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [141758-74-9]

SYNONYMS: Exenatide

RESEARCH AREA: Diabetes

REFERENCES:
J. Eng et al., J. Biol. Chem., 267(11), 7402 (1992)

SKU(s): EXED-003A, EXED-003B

KEYWORDS: