Description

Exendin (9-39) is a selective and potent against glucagon-like peptide 1 (GLP-1) and inhibits (Kd = 1.7 nm) cAMP production caused by Gastric Inhibitory Peptide (GIP). Exendin (9-39) is involved in appetite modulation by reducing insulin secretion and helps prevent sharp falls in glucose levels. This peptide has been studied for its? effects on the permeability of basal microvascular.

SEQUENCE: H-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2 (trifluoroacetate salt)

ONE-LETTER SEQUENCE: DLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2

MOLECULAR FORMULA: C₁₄₉H₂₃₄N₄₀O₄₇S

MOLECULAR WEIGHT: 3369.79

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [133514-43-9]

SYNONYMS: Exendin-(9-39)

RESEARCH AREA: Diabetes

REFERENCES:
Greig, NH. et al. Diabetolog 42, 45 (1999)
Montrose-Rafizadeh, C. et al. J Biol Chem 272, 21201 (1997)
Göke R. et al. J Biol Chem 268, 19650 (1993)
Eng, J. et al. J Biol Chem 267, 7402 (1992)

SKU(s): EXED-002A, EXED-002B

KEYWORDS: