Description

Potent vasoconstrictor that acts on endothelia cells and on the underlying smooth muscle cells as a modulator of vascular tone. ET-1 displays selectivity for ETA receptor.

SEQUENCE: H-Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-OH (ammonium acetate salt)
(Cys1 and 15 bridge, Cys3 and 11 bridge)

ONE-LETTER SEQUENCE: CSCSSLMDKECVYFCHLDIIW (C1&C15 bridge, C3&C11 bridge)

MOLECULAR FORMULA: C₁₀₉H₁₅₉N₂₅O₃₂S₅

MOLECULAR WEIGHT: 2492

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [117399-94-7]

SYNONYMS: ET-1 (human, bovine, dog, mouse, porcine, rat), Endothelin-1 (human, bovine, dog, mouse, porcine, rat)

RESEARCH AREA: Cardiovascular

REFERENCES:
A. Inoue, et al., PNAS, 80, 2863 (1989)
M. Yanagisawa et al., TIPS, 10, 374 (1989)
G.J. Price et al., Nucleic Acids Res., 18, 3658 (1991)

SKU(s): ENDT-001A, ENDT-001B, ENDT-001C

KEYWORDS: