Description

This peptide contain 6 conserved disulfide-linked cysteines. In vitro, it has a prominent antimicrobial activities against bacteria, fungi, and certain enveloped viruses. In addition, human and rabbit defensins exert potent cytotoxicity in vitro against various mammalian tumor cells.

SEQUENCE: H-Ala-Phe-Thr-Cys-His-Cys-Arg-Arg-Ser-Cys-Tyr-Ser-Thr-Glu-Tyr-Ser-Tyr-Gly-Thr-Cys-Thr-Val-Met-Gly-Ile-Asn-His-Arg-Phe-Cys-Cys-Leu-OH (trifluoroacetate salt)

(Cys4 and Cys31/Cys6 and Cys20/Cys10 and Cys30 Disulfide Bridges)

ONE-LETTER SEQUENCE: AFTCHCRRSCYSTEYSYGTCTVMGINHRFCCL (Cys4 and Cys31/Cys6 and Cys20/Cys10 and Cys30 Disulfide Bridges)

MOLECULAR FORMULA: C₁₅₆H₂₂₈N₄₆O₄₆S₇

MOLECULAR WEIGHT: 3708.27

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [136661-76-2]

SYNONYMS: α-Defensin 6

RESEARCH AREA: Antimicrobial

CATEGORY: Defensins »

REFERENCES:
P.A.Raj et al., Biochem. J., 347, 633 (2000)
Z.Wu et al., J. Pept. Res., 64, 118 (2004)
F.T.Lundy et al., Oral Oncol., 40, 139 (2004)
M.J.Nam et al., J. Biol. Chem., 280, 8260 (2005)
E.Hazrati et al., J. Immunol., 177, 8658 (2006)
A.Szyk et al., Protein Sci., 15, 2749 (2006)
M.E.Klotman et al., J. Immunol., 180, 6176 (2008)

SKU(s): DEFS-008A, DEFS-008B, DEFS-008C

KEYWORDS: