Description

This peptide contain 6 conserved disulfide-linked cysteines. In vitro, it has a prominent antimicrobial activities against bacteria, fungi, and certain enveloped viruses. In addition, human and rabbit defensins exert potent cytotoxicity in vitro against various mammalian tumor cells.

SEQUENCE: H-Asp-Cys-Tyr-Cys-Arg-Ile-Pro-Ala-Cys-Ile-Ala-Gly-Glu-Arg-Arg-Tyr-Gly-Thr-Cys-Ile-Tyr-Gln-Gly-Arg-Leu-Trp-Ala-Phe-Cys-Cys-OH (trifluoroacetate salt)
(Cys2 and Cys30/Cys4 and Cys19/Cys9 and Cys29 Bridge)

ONE-LETTER SEQUENCE: DCYCRIPACIAGERRYGTCIYQGRLWAFCC(Cys2 and Cys30/Cys4 and Cys19/Cys9 and Cys29 Bridge)

MOLECULAR FORMULA: C₁₅₁H₂₂₂N₄₄O₄₀S₆

MOLECULAR WEIGHT: 3486.09

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [136661-76-2]

SYNONYMS:

RESEARCH AREA: Antimicrobial

CATEGORY: Defensins »

REFERENCES:
P.A.Raj et al., Biochem. J., 347, 633 (2000)
F.T.Lundy et al., Oral Oncol., 40, 139 (2004)
Z.Wu et al., J. Pept. Res., 64, 118 (2004)

SKU(s): DEFS-007A, DEFS-007B, DEFS-007C

KEYWORDS: