Description

ACE2 peptidase domain (PD) α1 helix is important for binding SARS-CoV-2-RBD of the Spike (S) protein. The 23 residues selected from the ACE2 α1 helix sequence (IEEQAKTFLDKFNHEAEDLFYQS) specifically recognizes the SARS-CoV-2-RBD with sub-nanomolar binding. Binding by this peptide to the SARS-CoV-2-RBD may block the entry of the virus into the host cell.

SEQUENCE: H-Ile-Glu-Glu-Gln-Ala-Lys-Thr-Phe-Leu-Asp-Lys-Phe-Asn-His-Glu-Ala-Glu-Asp-Leu-Phe-Tyr-Gln-Ser-OH

ONE-LETTER SEQUENCE: IEEQAKTFLDKFNHEAEDLFYQS

MOLECULAR FORMULA: C₁₂₇H₁₈₄N₃₀O₄₂

MOLECULAR WEIGHT: 2803.15

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER:

SYNONYMS:

RESEARCH AREA: COVID-19-Related peptides

REFERENCES:
Zhang, G., S. Pomplun, A. R. Loftis, A. Loas, and B. L. Pentelute. “The first-in-class peptide binder to the SARS-CoV-2 spike protein. bioRxiv.” Doi 10, no. 2020.03: 19-999318.

SKU(s): COVD-008

KEYWORDS: