Description

This 14-amino acid peptide is an internally quenched FRET substrate for HCoV 229E main proteinase (Mpro) [also called: 3C-like protease (3CLpro)] with a similar cleavage site to picornavirus 3C proteinases. (K_m = 17 µM, K_cat = 1.9 s^-1)

SEQUENCE: Dabcyl-Lys-Thr-Ser-Ala-Val-Leu-Gln-Ser-Gly-Phe-Arg-Lys-Met-Glu-EDANS

ONE-LETTER SEQUENCE: Dabcyl-KTSAVLQSGFRKME-EDANS

MOLECULAR FORMULA: C₉₅H₁₄₁N₂₅O₂₄S₂

MOLECULAR WEIGHT: 2081.44

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [730985-86-1]

SYNONYMS: DABCYL-Lys-HCoV-SARS Replicase Polyprotein 1ab (3235-3246)-Glu-EDANS, DABCYL-Lys-pp1ab (3235-3246)-Glu-EDANS (Human coronavirus) (strain SARS), DABCYL-Lys-ORF1AB (3235-3246)-Glu-EDANS (Human coronavirus) (strain SARS)

RESEARCH AREA: COVID-19 Related Peptides

CITATIONS:
Yarovaya, Olga I., Aleksandr S. Filimonov, Dmitriy S. Baev, Sophia S. Borisevich, Anna V. Zaykovskaya, Varvara Yu Chirkova, Mariya K. Marenina et al. ” Viruses 16, no. 2 (2024): 215.

REFERENCES:
Kim, Yunjeong, et al. “Broad-spectrum antivirals against 3C or 3C-like proteases of picornaviruses, noroviruses, and coronaviruses.” Journal of Virology 86.21 (2012): 11754-11762.

SKU(s): COVD-001A, COVD-001B, COVD-001C

KEYWORDS: dye-labeled, FRET Substrate