Description

The peptide was found in the venom of the scorpionc Leiurus quinquestriatus, is a Ca2+-activated K+ channel blocker.

SEQUENCE: Glp-Phe-Thr-Asn-Val-Ser-Cys-Thr-Thr-Ser-Lys-Glu-Cys-Trp-Ser-Val-Cys-Gln-Arg-Leu-His-Asn-Thr-Ser-Arg-Gly-Lys-Cys-Met-Asn-Lys-Lys-Cys-Arg-Cys-Tyr-Ser-OH (trifluoroacetate salt)
(Cys7 and Cys28/Cys13 and Cys33/Cys17 and Cys35 Bridge)

ONE-LETTER SEQUENCE: Glp-FTNVSCTTSKECWSVCQRLHNTSRGKCMNKKCRCYS(Cys7 and Cys28/Cys13 and Cys33/Cys17 and Cys35 Bridge)

MOLECULAR FORMULA: C₁₇₆H₂₇₇N₅₇O₅₅S₇

MOLECULAR WEIGHT: 4295.95

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [95751-30-7]

SYNONYMS:

RESEARCH AREA: Toxin

CATEGORY: Charybdotoxin and Analogs »

REFERENCES:
G.Gimenez-Gallego et al., Proc. Natl. Acad. Sci. USA, 85, 3329 (1988)
R.MacKinnon and C.Miller, Science, 245, 1382 (1989)
N.A.Castle et al., Trends Neurosci., 12, 59 (1989)
T.R.Werkman et al., Neuroscience, 50, 935 (1992)
T.R.Jones et al., J. Appl. Physiol., 74, 1879 (1993)
C.Miller, Neuron, 15, 5 (1995)
K.G.Chandy et al., Trends Pharmacol. Sci., 25, 280 (2004)

SKU(s): CHAT-001A, CHAT-001B, CHAT-001C

KEYWORDS: