Description

CCK (27-33) is a C-terminal fragment of CCK peptide hormone found in the intestine and brain that stimulates digestion, mediates satiety, and is involved in anxiety. Non-sulfated CCK (27-33) inhibits binding of [3H]naloxone in rat cerebellum membranes (IC50 = 4 µM) and inhibits electrically-stimulated contraction of isolated guinea pig ileum (IC50 = 17 µM), an effect that can be reversed by naloxone.3 Unlike sulfated CCK (27-33), the non-sulfated form does not reduce exploratory behavior in mice when administered at doses up to 1 µmol/kg.

SEQUENCE: H-Tyr-Met-Gly-Trp-Met-Asp-Phe-NH2 (trifluoroacetate salt)

ONE-LETTER SEQUENCE: YMGWMDF-NH2

MOLECULAR FORMULA: C₄₅H₅₇N₉O₁₀S₂

MOLECULAR WEIGHT: 948.1

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [47910-79-2]

SYNONYMS:

RESEARCH AREA: Gastrointestinal

REFERENCES:
P.W. Schiller et al., BBRC, 85, 1332 (1978)
Raybould, H.E., and Lloyd, K.C. Ann. N.Y.Acad. Sci. 713(1), 143-156 (1994).
Ondetti, M.A., Pluščec, J., Sabo, E.F., et al. J. Am. Chem. Soc. 92(1), 195-199 (1970).

SKU(s): CCKS-007A, CCKS-007B

KEYWORDS: hormone