Description

Potent inhibitor for the poly(ADP-ribose) polymerase (PARP) cleavage by caspase-3 (IC50=0.2 nM). PARP cleavage occurs at the onset of apoptosis. This peptide aldehyde is useful in attenuating apoptotic events in vitro (IC50 = 10 nM).

SEQUENCE: Ac-Asp-Glu-Val-Asp-CHO

ONE-LETTER SEQUENCE: Ac-DEVD-CHO

MOLECULAR FORMULA: C₂₀H₃₀N₄O₁₁

MOLECULAR WEIGHT: 502.5

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [184179-08-6]

SYNONYMS: Caspase-3 Inhibitor I, N-Ac-Asp-Glu-Val-Asp-CHO

RESEARCH AREA: Apoptosis

REFERENCES:
D. Wissing et al., Proc. Natl. Acad. Sci. USA, 94, 5973 (1997)

SKU(s): CASP-050A, CASP-050B, CASP-050C, CASP-050D

KEYWORDS: aldehyde (CHO)