Description

CART (62-76) is a cocaine- and amphetamine-regulated transcript (CART) peptide fragment that inhibits food intake by attenuating NPY-induced feeding. It decreases food intake in food-restricted goldfish, and induces anxiogenic-like effects in elevated plus-maze test in rats. The peptide also modulates the activity of striatal noradrenergic, and corticostrial and hypothalamic serotoninergic systems, with no major effect on dopaminergic pathways in rat brain.

SEQUENCE: H-Tyr-Gly-Gln-Val-Pro-Met-Cys-Asp-Ala-Gly-Glu-Gln-Cys-Ala-Val-OH (trifluoroacetate salt)
(Cys68 and 74 bridge)

ONE-LETTER SEQUENCE: YGQVPMCDAGEQCAV (Cys68 and 74 bridge)

MOLECULAR FORMULA: C₆₄H₉₇N₁₇O₂₃S₃

MOLECULAR WEIGHT: 1568.76

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [210978-19-1]

SYNONYMS: CART (62-76) (rat, human), CART(62-76)(human,rat)

RESEARCH AREA: Obesity

REFERENCES:
Volkoff and Peter. Brain Res., 887, 125 (2000)
Vaarmann and Kask. Neuropeptides, 35, 292 (2001)
Colombo et al. Pancreas, 27, 161 (2003)

SKU(s): CART-003A, CART-003B

KEYWORDS: