Description

Salivary polypeptide shown to inhibit clostripain and a trypsin-like protease produced by Bacteroides gingivalis. Other proteases, however, are not inhibited by histatin-5. This peptide is thereby suggested to be a preventative against periodontal disease.

SEQUENCE: H-Asp-Ser-His-Ala-Lys-Arg-His-His-Gly-Tyr-Lys-Arg-Lys-Phe-His-Glu-Lys-His-His-Ser-His-Arg-Gly-Tyr-OH (trifluoroacetate salt)

ONE-LETTER SEQUENCE: DSHAKRHHGYKRKFHEKHHSHRGY

MOLECULAR FORMULA: C₁₃₃H₁₉₅N₅₁O₃₃

MOLECULAR WEIGHT: 3036.5

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [104339-66-4]

SYNONYMS:

RESEARCH AREA: Antimicrobial

REFERENCES:
M.Nishikata et al., Biochem. Biophys. Res. Commun., 174, 625 (1991)

SKU(s): ATBP-003A, ATBP-003B

KEYWORDS: