Description

Apamin, isolated from bee venom, is the smallest neurotoxic polypeptide, and also the only peptide that can pass the blood-brain barrier. This peptide blocks specifically the Ca2+-dependent K+ channels.

SEQUENCE: H-Cys-Asn-Cys-Lys-Ala-Pro-Glu-Thr-Ala-Leu-Cys-Ala-Arg-Arg-Cys-Gln-Gln-His-NH2 (trifluoroacetate salt)
(Cys1 and Cys11, Cys3 and Cys15 Bridge)

ONE-LETTER SEQUENCE: CNCKAPETALCARRCQQH-NH2 (Cys1&Cys11, Cys3&Cys15 Bridge)

MOLECULAR FORMULA: C₇₉H₁₃₁N₃₁O₂₄

MOLECULAR WEIGHT: 2027.37

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [24345-16-2]

SYNONYMS:

RESEARCH AREA: Toxin

REFERENCES:
J.Van Rietschoten et al., Eur. J. Biochem., 56, 35 (1975)
M.Hugues et al., Proc. Natl. Acad. Sci. USA, 79, 1308 (1982)

SKU(s): APAM-001A, APAM-001B

KEYWORDS: multiple disulfide bridges