Description

Angiotensin (1-7) acts as a vasodilator in the cardiovascular system and plays a significant role in the renin-angiotensin system (RAS). More recently, Angiotensin II (Ang II) is thought to play a role in preventing SARS-CoV-2 infection by binding to ACE2 receptors in the host cell. Since SARS-CoV-2 virus binds to ACE2 receptors, with 10–20 times the affinity of SARS-CoV-1 (ie: SARS-CoV), peptide-binding may, therefore, compete with the virus. Ang II is also known to bind to the AT1 receptor which causes internalization and downregulation of ACE2.

SEQUENCE: H-Asp-Arg-Val-Tyr-Ile-His-Pro-OH (trifluoroacetate salt)

ONE-LETTER SEQUENCE: DRVYIHP

MOLECULAR FORMULA: C₄₁H₆₂N₁₂O₁₁

MOLECULAR WEIGHT: 899.02

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [51833-78-4]

SYNONYMS:

RESEARCH AREA: Cancer, Cardiovascular

REFERENCES:
C. M. Ferrario et al., Hypertension, 18, III, 126 (1991)
Busse, L. W.; Chow, J. H.; McCurdy, M. T.; Khanna, A. K., BioMed Central: 2020.

SKU(s): ANGT-010A, ANGT-010B, ANGT-010C, ANGT-010D

KEYWORDS: