Description

37 amino acid polypeptide secreted from the beta cells of the pancreas and structurally related to calcitonin. It has anorectic effects in rats and may be responsible for the etiology of insulin resistance of type II diabetes mellitus through its modulation of peripheral effects of insulin. It blocks the activation of glycogen synthase by insulin.

SEQUENCE: H-Lys-Cys-Asn-Thr-Ala-Thr-Cys-Ala-Thr-Gln-Arg-Leu-Ala-Asn-Phe-Leu-Val-His-Ser-Ser-Asn-Asn-Phe-Gly-Ala-Ile-Leu-Ser-Ser-Thr-Asn-Val-Gly-Ser-Asn-Thr-Tyr-NH2 (trifluoroacetate salt)
(Cys2 and 7 bridge)

ONE-LETTER SEQUENCE: KCNTATCATQRLANFLVHSSNNFGAILSSTNVGSNTY-NH2 (C2&C7 bridge)

MOLECULAR FORMULA: C₁₆₅H₂₆₃N₅₁O₅₅S₂

MOLECULAR WEIGHT: 3903.33

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [122384-88-7]

SYNONYMS:

RESEARCH AREA: Diabetes

REFERENCES:

SKU(s): AMYN-006A, AMYN-006B

KEYWORDS: hormone