Description

Rat amylin (rIAPP) does not form fibrils like with human amylin (hIAPP). As a result, toxic effects have been reported for the human but not for the rat peptide amide. Diabetes-associated peptide.

SEQUENCE: H-Lys-Cys-Asn-Thr-Ala-Thr-Cys-Ala-Thr-Gln-Arg-Leu-Ala-Asn-Phe-Leu-Val-Arg-Ser-Ser-Asn-Asn-Leu-Gly-Pro-Val-Leu-Pro-Pro-Thr-Asn-Val-Gly-Ser-Asn-Thr-Tyr-NH2 (trifluoroacetate salt)
(Cys2 and 7 bridge)

ONE-LETTER SEQUENCE: KCNTATCATQRLANFLVRSSNNLGPVLPPTNVGSNTY-NH2 (C2&C7 bridge)

MOLECULAR FORMULA: C₁₆₇H₂₇₂N₅₂O₅₃S₂

MOLECULAR WEIGHT:

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [124447-81-0]

SYNONYMS: IAPP (mouse, rat), Islet amyloid polypeptide (mouse, rat)

RESEARCH AREA: Diabetes

REFERENCES:
E.R.Szabo et al., FASEB J., 26, 272 (2012)
J. Asai et al., BBRC, 164, 400 (1989)
J.Green et al., J. Mol. Biol., 326, 1147 (2003)
J.D.Leffert et al., Proc. Natl. Acad. Sci. USA, 86, 3127 (1989)
H.A.Golpon et al., Peptides, 24, 1157 (2003)

SKU(s): AMYN-004A, AMYN-004B

KEYWORDS: hormone