Description

37 amino acid polypeptide secreted from the β-cells of the pancreas and structurally related to calcitonin. It has anorectic effects in rats and may be responsible for the etiology of insulin resistance of type II diabetes mellitus through its modulation of peripheral effects of insulin. It blocks the activation of glycogen synthase by insulin.

SEQUENCE: H-Lys-Cys-Asn-Thr-Ala-Thr-Cys-Ala-Thr-Gln-Arg-Leu-Ala-Asn-Phe-Leu-Val-His-Ser-Ser-Asn-Asn-Phe-Gly-Ala-Ile-Leu-Ser-Ser-Thr-Asn-Val-Gly-Ser-Asn-Thr-Tyr-OH (trifluoroacetate salt)
(Cys2 and 7 bridge)

ONE-LETTER SEQUENCE: KCNTATCATQRLANFLVHSSNNFGAILSSTNVGSNTY (C2&C7 bridge)

MOLECULAR FORMULA: C₁₆₅H₂₆₂N₅₀O₅₆S₂

MOLECULAR WEIGHT: 3904.5

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [122384-88-7]

SYNONYMS: IAPP (human), IAPP 1-37, Islet Amyloid Polypeptide (human), Amlintide, Amylin, amide, human

RESEARCH AREA: Diabetes

REFERENCES:
K.Pillay and P.Govender, Biomed. Res. Int., 826706 (2013)
L.Khemtémourian et al., Exp. Diabetes Res., ID421287 (2008)
G.T.Westermark and P.Westermark, Exp. Diabetes Res., 528354 (2008)
D.H.Lopes et al., J. Biol. Chem., 279, 42803 (2004)
L.Marzban et al., Exp. Gerontol., 38, 347 (2003)
E.Rhoades and A.Gafni, Biophys. J., 84, 3480 (2003)
J.Eriksson et al., Diabetologia, 35, 291 (1992)
G.J.S.Cooper et al., Proc. Natl. Acad. Sci. USA, 84, 8628 (1987)

SKU(s): AMYN-001A, AMYN-001B

KEYWORDS: hormone