Description

Novel polypeptide that suppresses neuronal cell death induced by several familial Alzheimer’s disease genes and by amyloid beta-protein (human). The secretion of amyloid beta-protein (1-40) and amyloid beta protein (1-42) has been shown not to be affected by humanin in F11 cells expressing the familial Alzheimer’s disease gene K595N/M596L-APP. Inhibitory actions on neuronal cell death triggered by K595N/M596L-APP directly and caused by amyloid beta-protein have been suggested.

SEQUENCE: H-Met-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Ser-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala-OH (trifluoroacetate salt)

ONE-LETTER SEQUENCE: MAPRGFSCLLLLTSEIDLPVKRRA

MOLECULAR FORMULA: C₁₁₉H₂₀₄N₃₄O₃₂S₂

MOLECULAR WEIGHT: 2687.3

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [330936-69-1]

SYNONYMS:

RESEARCH AREA: Alzheimer’s Disease

REFERENCES:
Y. Hashimoto et al., Proc. Natl. Acad. Sci. USA , 98, 6336 (2001)
Y. Hashimoto et al., Biochem. Biophys. Res. Commun., 283, 460 (2001)

SKU(s): AMYD-118A, AMYD-118B

KEYWORDS: