Description

beta-sheet breaker peptide iAbeta5p that crosses the blood-brain barrier at a higher rate than most proteins and peptides. It is known to be selectively taken up by the brain, thereby suggesting that the peptide is being specifically transported to the brain. A significant increase in neuronal survival and decrease in brain inflammation associated with the reduction of amyloid plaques in two different transgenic Alzheimer’s disease (AD) models is additionally reported for this pentapeptide. Abeta (1-42) Fibrillogenesis Inhibitor.

SEQUENCE: Ac-Leu-Pro-Phe-Phe-Asp-NH2

ONE-LETTER SEQUENCE: Ac-LPFFD-NH2

MOLECULAR FORMULA: C₃₅H₄₆N₆O₈

MOLECULAR WEIGHT: 678.79

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [339990-02-2]

SYNONYMS: Acetyl-(Pro¹⁸,Asp²¹)-Amyloid β-Protein (17-21) amide

RESEARCH AREA: Alzheimer’s Disease

REFERENCES:

SKU(s): AMYD-033A, AMYD-033B

KEYWORDS: