Description

42-residue peptide believed to be the major subunit of the vascular and plaque filaments in individuals with Alzheimer’s disease, elderly people and patients with Trisomy 21 (Down’s Syndrome). Inactive control.

SEQUENCE: H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH

ONE-LETTER SEQUENCE: DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA

MOLECULAR FORMULA: C₂₀₃H₃₁₁N₅₅O₆₀S₁

MOLECULAR WEIGHT: 4514.04

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [107761-42-2]

SYNONYMS: Amyloid beta-Protein (1-42), Abeta42

RESEARCH AREA: Alzheimer’s Disease

REFERENCES:
J.Kang et al., Nature, 325, 733 (1987)
D.Goldgaber et al., Science, 235, 877 (1987)
J.Murrell et al., Science, 254, 97 (1991)
Neurobiology of Aging, 13, No.5 (1992)
G.Bitan et al., Proc. Natl. Acad. Sci. USA, 100, 330 (2003)
A.Jan et al., Nat. Protoc., 5, 1186 (2010)
W.B.Stine et al., Methods Mol. Biol. , 670, 13 (2011)

CITATIONS:
Walker, Douglas G., et al. Cells 8, no. 7 (2019): 766 »
Yen, Kelvin, et al. Scientific Reports 8.1 (2018): 14212 »
Hopping, Gene, et al. Elife 3 (2014): e01681 »
Scimemi, Annalisa, et al.Acta Pharmacologica Sinica 30.4 (2009): 388-395 »
Qin, Zhen-xia, et. al. Acta Pharmacologica Sinica 30.4 (2009): 388-395 »
Qin, Zhenxia, et al. Neuroscience Letters 444.3 (2008): 217-221 »

SKU(s): AMYD-003A, AMYD-003B

KEYWORDS: