Description

Precursor of adrenomedullin containing proadrenomedullin NH2-terminal 20 peptide (PAMP), a unique 20-residue sequence. When administered, PAMP produces a strong and rapid hypotensive effect in anesthetized rats. PAMP has also been suggested to function as an inhibitory modulator of renal noradrenergic neurotransmission, thereby playing an important role in the regulation of renal functions. PAMP has been proposed to serve as an inhibitory regulator in adrenal catecholamine release in vivo and possesses a potent hyperglycemic effect after intra-third cerebroventricular administration in fasted mice.

SEQUENCE: H-Ala-Arg-Leu-Asp-Val-Ala-Ser-Glu-Phe-Arg-Lys-Lys-Trp-Asn-Lys-Trp-Ala-Leu-Ser-Arg-NH2 (trifluoroacetate salt)

ONE-LETTER SEQUENCE: ARLDVASEFRKKWNKWALSR-NH2

MOLECULAR FORMULA: C₁₁₂H₁₇₈N₃₆O₂₇

MOLECULAR WEIGHT: 2460.9

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [150238-87-2]

SYNONYMS:

RESEARCH AREA: Cardiovascular

REFERENCES:
K. Kitamura et al., BBRC, 194, 720 (1993)

SKU(s): ADRM-007A, ADRM-007B

KEYWORDS: