Description

Relaxin H2 (human) is a naturally occurring peptide hormone belonging to the relaxin family of insulin-like peptides. It plays a key role in various physiological processes, including reproductive health, tissue remodeling, cardiovascular regulation, and antifibrotic activity. The human Relaxin H2 form is the primary circulating isoform in humans and exhibits potent vasodilatory, anti-inflammatory, and antifibrotic properties.

The Relaxin H2 peptide is composed of two peptide chains (A-chain and B-chain), connected by disulfide bonds, resembling the structural framework of insulin. The B-chain is essential for receptor binding and activation, primarily interacting with Relaxin Family Peptide Receptor 1 (RXFP1).

SEQUENCE: Chain A: Glp-Leu-Tyr-Ser-Ala-Leu-Ala-Asn-Lys-Cys-Cys-His-Val-Gly-Cys-Thr-Lys-Arg-Ser-Leu-Ala-Arg-Phe-Cys-OH-InterDimer-Chain B: Asp-Ser-Trp-Met-Glu-Glu-Val-Ile-Lys-Leu-Cys-Gly-Arg-Glu-Leu-Val-Arg-Ala-Gln-Ile-Ala-Ile-Cys-Gly-Met-Ser-Thr-Trp-Ser-OH (Chain A Cys10 and Cys15, Chain A Cys11 and Chain B Cys11; Chain A Cys24 and Chain B Cys23)

ONE-LETTER SEQUENCE: Glp-LYSALANKCCHVGCTKRSLARFC-InterDimer-DSWMEEVIKLCGRELVRAQIAICGMSTWS (Chain A Cys10 and Cys15, Chain A Cys11 and Chain B Cys11; Chain A Cys24 and Chain B Cys23)

MOLECULAR FORMULA: C₂₅₆H₄₀₈N₇₄O₇₄S₈
MOLECULAR WEIGHT: 5963.04

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [99489-94-8]

SYNONYMS: Human Relaxin-2, H2 Relaxin, RLN2, Relaxin Peptide Hormone, Insulin-like Peptide H2, Relaxin, Human, Prorelaxin, Relaxin-2 Precursor,Relaxin A/B Chain, Serelaxin

RESEARCH AREA: Cardiovascular, Reproductive, Anti-Inflammatory, Cancer

SKU(s): 966545A, 966545B, 966545C

KEYWORDS: Antifibrotic, Cardioprotective, Vasodilation, Tissue Remodeling, Reproductive Health

REFERENCES:

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