Description

Chlorotoxin is a chloride channel blocker originally isolated from the venom of the deathstalker scorpion. This 36-mer peptide also selectively binds to glioma cells which have made it a candidate for cancer therapeutics.

SEQUENCE: H-Met-Cys-Met-Pro-Cys-Phe-Thr-Thr-Asp-His-Gln-Met-Ala-Arg-Lys-Cys-Asp-Asp-Cys-Cys-Gly-Gly-Lys-Gly-Arg-Gly-Lys-Cys-Tyr-Gly-Pro-Gln-Cys-Leu-Cys-Arg-NH2 (trifluoroacetate salt)
(Disulfide Bridge: Cys1-Cys4, Cys2-Cys6, Cys3-Cys7, Cys5-Cys8)

ONE-LETTER SEQUENCE: MCMPCFTTDHQMARKCDDCCGGKGRGKCYGPQCLCR-NH2

MOLECULAR FORMULA: C₁₅₈H₂₄₉N₅₃O₄₇S₁₁

MOLECULAR WEIGHT: 3995.77

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [163515-35-3]

SYNONYMS:

RESEARCH AREA: Toxin

REFERENCES:
DeBin JA, Strichartz GR. Toxicon 29 (11): 1403, 8, (1991).
Deshane J, Garner CC, Sontheimer H . J. Biol. Chem. 278 (6): 4135, 44, (2003).

SKU(s): CLTX-001A, CLTX-001B

KEYWORDS: